Bmal1^em1Bwu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Bmal1^em1Bwu
• Name: basic helix-loop-helix ARNT like 1; endonuclease-mediated mutation 1, Baojian Wu
• MGI ID: MGI:7488133
• Synonyms: Bmal1^-
• Gene: Bmal1 Location: Chr7:112806672-112913333 bp, + strand Genetic Position: Chr7, 59.17 cM, cytoband F2-F3
• Alliance: Bmal1^em1Bwu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted a portion of exon 5. (J:267593, J:281932)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bmal1 Mutation: 137 strains or lines available

References

• Original: J:267593 Wang S, et al., REV-ERBalpha integrates colon clock with experimental colitis through regulation of NF-kappaB/NLRP3 axis. Nat Commun. 2018 Oct 12;9(1):4246
• All: 5 reference(s)