Prkcd^tm1.1Shb
Targeted Allele Detail

Summary

• Symbol: Prkcd^tm1.1Shb
• Name: protein kinase C, delta; targeted mutation 1.1, Satoru Arata
• MGI ID: MGI:7486758
• Gene: Prkcd Location: Chr14:30317311-30348167 bp, - strand Genetic Position: Chr14, 18.82 cM
• Alliance: Prkcd^tm1.1Shb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:307392
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct inserted a loxP site and PGK-neo cassette upstream of exon 7 and a loxP site downstream of exon 7. Cre-mediated recombination removed exon 7. (J:307392)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prkcd Mutation: 52 strains or lines available

References

• Original: J:307392 Niino YS, et al., PKCdelta deficiency inhibits fetal development and is associated with heart elastic fiber hyperplasia and lung inflammation in adult PKCdelta knockout mice. PLoS One. 2021;16(7):e0253912
• All: 1 reference(s)