Msr1^{tm1(HBEGF)Mtka}
Targeted Allele Detail

Summary

• Symbol: Msr1^{tm1(HBEGF)Mtka}
• Name: macrophage scavenger receptor 1; targeted mutation 1, Masato Tanaka
• MGI ID: MGI:7486751
• Synonyms: CD204-DTR
• Gene: Msr1 Location: Chr8:40034726-40095714 bp, - strand Genetic Position: Chr8, 23.89 cM
• Alliance: Msr1^{tm1(HBEGF)Mtka} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:336137
• Parent Cell Line: B6JN/1 (ES Cell)
• Strain of Origin: (C57BL/6N x C57BL/6J)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Msr1^{tm1(HBEGF)Mtka} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Msr1^{tm1(HBEGF)Mtka} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Msr1 (MGI:98257)

• Mutation details: Targeting introduced the human Diphtheria toxin receptor (DTR) and FRT-flanked neomycin resistance cassette into the locus. (J:336137)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Msr1 Mutation: 12 strains or lines available

References

• Original: J:336137 Uchida Y, et al., CD204-positive monocytes and macrophages ameliorate septic shock by suppressing proinflammatory cytokine production in mice. Biochem Biophys Rep. 2020;23:100791
• All: 1 reference(s)