Aire^tm2Ghr
Targeted Allele Detail

Summary

• Symbol: Aire^tm2Ghr
• Name: autoimmune regulator; targeted mutation 2, Georg A Hollander
• MGI ID: MGI:7486746
• Synonyms: Aire^GFP
• Gene: Aire Location: Chr10:77865856-77879444 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Aire^tm2Ghr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274436
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A loxP-flanked enhanced green fluorescent protein (EGFP), PGK-neomycin, and triple polyA signal replaced exon 1. (J:274436)

Expression

In Mice Carrying this Mutation:

3 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aire Mutation: 55 strains or lines available

References

• Original: J:274436 Sansom SN, et al., Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia. Genome Res. 2014 Dec;24(12):1918-31
• All: 3 reference(s)