Pkn3^tm1.1Hmuk
Targeted Allele Detail

Summary

• Symbol: Pkn3^tm1.1Hmuk
• Name: protein kinase N3; targeted mutation 1.1, Hideyuki Mukai
• MGI ID: MGI:7486199
• Gene: Pkn3 Location: Chr2:29967696-29981034 bp, + strand Genetic Position: Chr2, 21.13 cM
• Alliance: Pkn3^tm1.1Hmuk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:250178
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeting construct replaced exons 17 through 20 with a floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. (J:250178)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkn3 Mutation: 55 strains or lines available

References

• Original: J:250178 Mukai H, et al., PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Sci Rep. 2016 Jan 8;6:18979
• All: 1 reference(s)