Prickle2^tm1Hmd
Targeted Allele Detail

Summary

• Symbol: Prickle2^tm1Hmd
• Name: prickle planar cell polarity protein 2; targeted mutation 1, Hiroshi Hamada
• MGI ID: MGI:7484672
• Gene: Prickle2 Location: Chr6:92347889-92683136 bp, - strand Genetic Position: Chr6, 41.05 cM
• Alliance: Prickle2^tm1Hmd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:240026
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct inserted a loxP site upstream of exon 6 and an FRT-flanked neomycin resistance cassette with a 3' loxP site downstream of exon 6. (J:240026)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prickle2 Mutation: 51 strains or lines available

References

• Original: J:240026 Minegishi K, et al., A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017 Mar 13;40(5):439-452.e4
• All: 1 reference(s)