Rr421^em1Itok
Endonuclease-mediated Allele Detail

Summary

• Symbol: Rr421^em1Itok
• Name: regulatory region 421; endonuclease-mediated mutation 1, Kosei Ito
• MGI ID: MGI:7484545
• Synonyms: mR2^m
• Gene: Rr421 Location: Chr15:61856689-61856694 bp Genetic Position: Chr15, Syntenic
• Alliance: Rr421^em1Itok page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Modified regulatory region)
• Mutation: Nucleotide substitutions
• CRISPR-cas9 mediated recombination replaced the regulatory sequence (TGCGGT) with AGATCT. (J:319454)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rr421 Mutation: 0 strains or lines available

References

• Original: J:319454 Otani S, et al., Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. Oncogene. 2022 Jan;41(5):683-691
• All: 1 reference(s)