Trh^em1(dre)Lowl
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trh^em1(dre)Lowl
• Name: thyrotropin releasing hormone; endonuclease-mediated mutation 1,Bradford B Lowell
• MGI ID: MGI:7482625
• Synonyms: Trh-p2a-Dre
• Gene: Trh Location: Chr6:92219042-92221631 bp, - strand Genetic Position: Chr6, 41.03 cM
• Alliance: Trh^em1(dre)Lowl page

Mutation origin

• Strain of Origin: FVB

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Trh^em1(dre)Lowl expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Trh (MGI:98823)

• Mutation details: Using the CRISPR/Cas9 system, the p2a-Dre recombinase cassette was inserted in front of the Trh stop codon TAA in the 2nd exon of the Trh gene. (J:335546)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Trh (mouse) Summary of all recombinase alleles driven by Trh. Comparative matrix view of recombinase activities Alliance mouse Trh gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trh Mutation: 22 strains or lines available

References

• Original: J:335546 Grzelka K, et al., A synaptic amplifier of hunger for regaining body weight in the hypothalamus. Cell Metab. 2023 May 2;35(5):770-785.e5
• All: 1 reference(s)