Rapgef4^tm2Ics
Targeted Allele Detail

Summary

• Symbol: Rapgef4^tm2Ics
• Name: Rap guanine nucleotide exchange factor (GEF) 4; targeted mutation 2, Mouse Clinical Institute
• MGI ID: MGI:7481949
• Synonyms: EPAC2 flox
• Gene: Rapgef4 Location: Chr2:71811584-72087818 bp, + strand Genetic Position: Chr2, 42.9 cM, cytoband C3
• Alliance: Rapgef4^tm2Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335537
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Exon 17 was flanked by loxP sites. (J:335537)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rapgef4 Mutation: 66 strains or lines available

References

• Original: J:335537 Guillot B, et al., Inhibition of EPAC1 signaling pathway alters atrial electrophysiology and prevents atrial fibrillation. Front Physiol. 2023;14:1120336
• All: 1 reference(s)