Swap70^em1Jpliu
Endonuclease-mediated Allele Detail

Summary

• Symbol: Swap70^em1Jpliu
• Name: SWA-70 protein; endonuclease-mediated mutation 1, Jinping Liu
• MGI ID: MGI:7471262
• Gene: Swap70 Location: Chr7:109820918-109882713 bp, + strand Genetic Position: Chr7, 57.7 cM
• Alliance: Swap70^em1Jpliu page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology generated a 1-bp insertion in exon 2, changing the 221 to 222 bases from AC into AAC to silence the expression of Swap70. Western blot analysis confirmed the absence of protein in heart. (J:335520)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Swap70 Mutation: 34 strains or lines available

References

• Original: J:335520 Qian Q, et al., SWAP70 Overexpression Protects Against Pathological Cardiac Hypertrophy in a TAK1-Dependent Manner. J Am Heart Assoc. 2023 Apr 4;12(7):e028628
• All: 1 reference(s)