Ttyh1^{em1(icre/ERT2)Minz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ttyh1^{em1(icre/ERT2)Minz}
• Name: tweety family member 1; endonuclease-mediated mutation 1, Min-hua Zheng
• MGI ID: MGI:7469841
• Synonyms: Ttyh1-CreERT2
• Gene: Ttyh1 Location: Chr7:4122418-4139206 bp, + strand Genetic Position: Chr7, 2.38 cM, cytoband A1
• Alliance: Ttyh1^{em1(icre/ERT2)Minz} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Ttyh1^{em1(icre/ERT2)Minz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ttyh1 (MGI:1889007)

• Mutation details: Using the CRISPR/Cas9 system, P2A-iCreERT2 cassette was inserted at exon 13 of the Ttyh1 gene with its ORF intact. (J:335386)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ttyh1 (mouse) Summary of all recombinase alleles driven by Ttyh1. Comparative matrix view of recombinase activities Alliance mouse Ttyh1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ttyh1 Mutation: 44 strains or lines available

References

• Original: J:335386 Cao Y, et al., Transmembrane Protein Ttyh1 Maintains the Quiescence of Neural Stem Cells Through Ca(2+)/NFATc3 Signaling. Front Cell Dev Biol. 2021;9:779373
• All: 1 reference(s)