Il3ra^em1Fksw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il3ra^em1Fksw
• Name: interleukin 3 receptor, alpha chain; endonuclease-mediated mutation 1, Filip K Swirski
• MGI ID: MGI:7469629
• Synonyms: Il3ra^fl
• Gene: Il3ra Location: Chr14:8114270-8123851 bp, - strand Genetic Position: Chr14, 7.08 cM
• Alliance: Il3ra^em1Fksw page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology flanked exons 2-11 with loxP sites and inserted a P2A and EGFP between exon 11 and the second loxP site. Missense mutations were identified that result in the quenching of the GFP signal but do not influence IL-3Ralpha functionality or signaling. (J:335093)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il3ra Mutation: 37 strains or lines available

References

• Original: J:335093 McAlpine CS, et al., Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature. 2021 Jul;595(7869):701-706
• All: 1 reference(s)