Il3^em1Fksw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il3^em1Fksw
• Name: interleukin 3; endonuclease-mediated mutation 1, Filip K Swirski
• MGI ID: MGI:7469627
• Synonyms: Il3^GFPfl
• Gene: Il3 Location: Chr11:54156129-54158103 bp, - strand Genetic Position: Chr11, 32.13 cM, cytoband B1
• Alliance: Il3^em1Fksw page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, Reporter)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology flanked exons 2-5 with loxP sites and inserted a P2A and EGFP between exon 5 and the second loxP site. (J:335093)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il3 Mutation: 23 strains or lines available

References

• Original: J:335093 McAlpine CS, et al., Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease. Nature. 2021 Jul;595(7869):701-706
• All: 3 reference(s)