Tg(APOL1*)G1Mrpk
Transgene Detail

Summary

• Symbol: Tg(APOL1*)G1Mrpk
• Name: transgene insertion G1, Martin R Pollak
• MGI ID: MGI:7469462
• Synonyms: APOL1^G1
• Transgene: Tg(APOL1*)G1Mrpk Location: unknown Genetic Position: Chr4, Syntenic
• Alliance: Tg(APOL1*)G1Mrpk page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The transgene contains a human library clone (CTD2333M18) with 100,104 bp clone contained the APOL1 gene about 25 kB of upstream (including exons 1-5 of the APOL2 gene) and about 65 kB of downstream (including exons 4-41 of the MYH9 gene) sequence. The APOL1 G0 sequence was modified to include the amino acids E150, I228, and K255, which is identical to the G1 haplotype. (J:322919)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:322919 McCarthy GM, et al., Recessive, gain-of-function toxicity in an APOL1 BAC transgenic mouse model mirrors human APOL1 kidney disease. Dis Model Mech. 2021 Aug 1;14(8):dmm048952
• All: 1 reference(s)