Mettl3^em1Qzh
Chemically induced Allele Detail

Summary

• Symbol: Mettl3^em1Qzh
• Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit; endonuclease-mediated mutation 1, Qi Zhou
• MGI ID: MGI:7468836
• Synonyms: Mettl3^fl
• Gene: Mettl3 Location: Chr14:52532298-52542585 bp, - strand Genetic Position: Chr14, 26.88 cM, cytoband C1
• Alliance: Mettl3^em1Qzh page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Mutation description

• Allele Type: Chemically induced (ENU) (Conditional ready)
• Mutation: Insertion
• Exons 2 to 4 were flanked by loxP sites via CRISPR/Cas9 technology. (J:263687)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mettl3 Mutation: 45 strains or lines available

References

• Original: J:263687 Wang CX, et al., METTL3-mediated m6A modification is required for cerebellar development. PLoS Biol. 2018 Jun;16(6):e2004880
• All: 4 reference(s)