Cdc20^em1Jko
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdc20^em1Jko
• Name: cell division cycle 20; endonuclease-mediated mutation 1, Keio University School of Medicine
• MGI ID: MGI:7467426
• Synonyms: Cdc20^{em1(R286S)Jko}
• Gene: Cdc20 Location: Chr4:118290098-118294540 bp, - strand Genetic Position: Chr4, 54.61 cM
• Alliance: Cdc20^em1Jko page

Mutation origin

• Strain of Origin: (C57BL/6J x DBA/2J)F2

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution of arginine with serine at position 286 (R286S). (J:335165)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdc20 Mutation: 30 strains or lines available

References

• Original: J:335165 Fujita H, et al., Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation. Aging Cell. 2020 Nov;19(11):e13251
• All: 1 reference(s)