Sqstm1^tm1Jsho
Targeted Allele Detail

Summary

• Symbol: Sqstm1^tm1Jsho
• Name: sequestosome 1; targeted mutation 1, Junichi Shoda
• MGI ID: MGI:7467229
• Synonyms: p62^KI
• Gene: Sqstm1 Location: Chr11:50090193-50101654 bp, - strand Genetic Position: Chr11, 30.36 cM, cytoband B1.2
• Alliance: Sqstm1^tm1Jsho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:335151
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site, a transcription termination signal (STOP), FRT-flanked neomycin resistance gene cassette, and second loxP site were inserted into the intron between exons 1 and 2. Western blot analysis confirmed absence of protein in quadriceps, liver, and white adipose tissue. (J:335151)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sqstm1 Mutation: 35 strains or lines available

References

• Original: J:335151 Miura I, et al., p62/Sqstm1 rescue in muscle retards the progression of steatohepatitis in p62/Sqstm1-null mice fed a high-fat diet. Front Physiol. 2022;13:993995
• All: 1 reference(s)