Cldn18^{tm1.1(cre/ERT2)Geno}
Targeted Allele Detail

Summary

• Symbol: Cldn18^{tm1.1(cre/ERT2)Geno}
• Name: claudin 18; targeted mutation 1.1, Genoway
• MGI ID: MGI:7467158
• Synonyms: Cldn18-IRES-CreERT2
• Gene: Cldn18 Location: Chr9:99572849-99599320 bp, - strand Genetic Position: Chr9, 52.0 cM, cytoband E3-F1
• Alliance: Cldn18^{tm1.1(cre/ERT2)Geno} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:317989
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Cldn18^{tm1.1(cre/ERT2)Geno} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Cldn18 (MGI:1929209)

• Mutation details: The allele is generated by homologous recombination in embryonic SCs targeting the IRES-CreERT2 cassette into the 3 untranslated region of the Cldn18 gene after exon 5 on chromosome 9. The neomycin selection cassette was removed subsequently. (J:317989)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Cldn18 (mouse) Summary of all recombinase alleles driven by Cldn18. Comparative matrix view of recombinase activities Alliance mouse Cldn18 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn18 Mutation: 20 strains or lines available

References

• Original: J:317989 Fatehullah A, et al., A tumour-resident Lgr5(+) stem-cell-like pool drives the establishment and progression of advanced gastric cancers. Nat Cell Biol. 2021 Dec;23(12):1299-1313
• All: 1 reference(s)