Gt(ROSA)26Sor^{tm1.1(CAG-gluc*)1Harv}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(CAG-gluc*)1Harv}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Brandon Harvey
• MGI ID: MGI:7466787
• Synonyms: Tg(CAG-gluc*)1Harv, Tg(GLuc-SERCaMP)
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(CAG-gluc*)1Harv} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:340162
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A vector containing ROSA26 homology arms, a CAG promoter, flox stop sequence, and Gaussia luciferase with ASARTDL tail (secreted ER calcium-monitoring protein or SERCaMP) and a FRT-flanked Neomycin gene was inserted into the Gt(ROSA)26Sor locus. The neomycin cassette was removed in the germline via FLP-mediated recombination. (J:340162)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:340162 Svarcbahs R, et al., A transgenic mouse line for assaying tissue-specific changes in endoplasmic reticulum proteostasis. Transgenic Res. 2023 Jun;32(3):209-221
• All: 1 reference(s)