Ltn1^em1Mota
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ltn1^em1Mota
• Name: listerin E3 ubiquitin protein ligase 1; endonuclease-mediated mutation 1, Motomasa Tanaka
• MGI ID: MGI:7465090
• Gene: Ltn1 Location: Chr16:87173539-87229500 bp, - strand Genetic Position: Chr16, 49.52 cM
• Alliance: Ltn1^em1Mota page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas technology generated a 10-bp deletion in exon 1. (J:335017)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltn1 Mutation: 95 strains or lines available

References

• Original: J:335017 Endo R, et al., Dysregulation of ribosome-associated quality control elicits cognitive disorders via overaccumulation of TTC3. Proc Natl Acad Sci U S A. 2023 Mar 21;120(12):e2211522120
• All: 1 reference(s)