Zbp1^em1Aob
Endonuclease-mediated Allele Detail

Summary

• Symbol: Zbp1^em1Aob
• Name: Z-DNA binding protein 1; endonuclease-mediated mutation 1, Andrew Oberst
• MGI ID: MGI:7464905
• Synonyms: Zbp1^A64P
• Gene: Zbp1 Location: Chr2:173048405-173060715 bp, - strand Genetic Position: Chr2, 95.83 cM, cytoband H3
• Alliance: Zbp1^em1Aob page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR/Cas9 technology generated a G to C nucleotide change resulting in an alanine to proline substitution at amino acid 64 (p.A64P). (J:331943)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbp1 Mutation: 29 strains or lines available

References

• Original: J:331943 Hubbard NW, et al., ADAR1 mutation causes ZBP1-dependent immunopathology. Nature. 2022 Jul;607(7920):769-775
• All: 1 reference(s)