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Endonuclease-mediated Allele Detail
Symbol: Rhobtb2em1(IMPC)J
Name: Rho-related BTB domain containing 2; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:7464782
Gene: Rhobtb2  Location: Chr14:70022439-70043085 bp, - strand  Genetic Position: Chr14, 36.1 cM, cytoband D1
Alliance: Rhobtb2em1(IMPC)J page
IMPC: Rhobtb2 gene page
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences TGGCAATTCCGAATAATAAG and CTCCACGCTGAGCGGAAGCA, which resulted in a 3821 bp deletion beginning at Chromosome 14 position 69,796,110 bp and ending after 69,799,930 bp (GRCm38/mm10). This mutation deletes ENSMUSE00000556573, ENSMUSE00000123406, ENSMUSE00000263693 (exons 3,4, and 5) and 2512 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 64 and early truncation 1 amino acid later. (J:188991)
Inheritance:    Not Specified
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Rhobtb2 Mutation:  25 strains or lines available
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
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