Grem1^{tm1(Hbegf/tdTomato)Shiv}
Targeted Allele Detail

Summary

• Symbol: Grem1^{tm1(Hbegf/tdTomato)Shiv}
• Name: gremlin 1, DAN family BMP antagonist; targeted mutation 1, Ramesh Shivdasani
• MGI ID: MGI:7464726
• Synonyms: Grem1-P2A-DTR-P2A-TdTomato, Grem1tdTom
• Gene: Grem1 Location: Chr2:113579020-113588993 bp, - strand Genetic Position: Chr2, 57.43 cM
• Alliance: Grem1^{tm1(Hbegf/tdTomato)Shiv} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:334878
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Grem1^{tm1(Hbegf/tdTomato)Shiv} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• A P2A-DTR-P2A-TdTomato construct was inserted at the translational stop codon TAA in the gene. (J:334878)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grem1 Mutation: 19 strains or lines available

Notes

FL19 ES cells were used in the generation of this allele.

References

• Original: J:334878 Kraiczy J, et al., Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche. Cell Stem Cell. 2023 Apr 6;30(4):433-449.e8
• All: 3 reference(s)