Clec11a^{em3(cre/ERT2)Sjm}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Clec11a^{em3(cre/ERT2)Sjm}
• Name: C-type lectin domain family 11, member a; endonuclease-mediated mutation 3, Sean Morrison
• MGI ID: MGI:7464488
• Synonyms: Oln^iCreER
• Gene: Clec11a Location: Chr7:43953190-43956383 bp, - strand Genetic Position: Chr7, 28.83 cM, cytoband B3-B5
• Alliance: Clec11a^{em3(cre/ERT2)Sjm} page

Mutation origin

• Strain of Origin: C57BL/Ka

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Null/knockout, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Clec11a^{em3(cre/ERT2)Sjm} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Clec11a (MGI:1298219)

• Mutation details: CRISPR-Cas9 methods were used to insert iCreER sequence to replace the exons 1 and 2 of the Clec11a (Oln) gene. (J:334856)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Clec11a (mouse) Summary of all recombinase alleles driven by Clec11a. Comparative matrix view of recombinase activities Alliance mouse Clec11a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec11a Mutation: 15 strains or lines available

References

• Original: J:334856 Shen B, et al., A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis. Nature. 2021 Mar;591(7850):438-444
• All: 1 reference(s)