Trpv3^em1Amag
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trpv3^em1Amag
• Name: transient receptor potential cation channel, subfamily V, member 3; endonuclease-mediated mutation 1, Masayuki Amagai
• MGI ID: MGI:7461816
• Gene: Trpv3 Location: Chr11:73158315-73191194 bp, + strand Genetic Position: Chr11, 45.25 cM
• Alliance: Trpv3^em1Amag page

Mutation origin

• Strain of Origin: (C57BL/6N x Hos:HR-1)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-cas9 mediated recombination using guide RNAs created a 8512 bp deletion resulting in a 333 bp PCR product.. (J:309472)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpv3 Mutation: 56 strains or lines available

References

• Original: J:309472 Matsui T, et al., A unique mode of keratinocyte death requires intracellular acidification. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2020722118
• All: 1 reference(s)