Gt(ROSA)26Sor^{tm1(CAG-APOBEC3B)Rshar}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-APOBEC3B)Rshar}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Reuben S Harris
• MGI ID: MGI:7461466
• Synonyms: Rosa26::CAG-LSL-A3Bi, Rosa26::LSL-CAG-A3B
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-APOBEC3B)Rshar} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:341577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1(CAG-APOBEC3B)Rshar} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  APOBEC3B (9582)

  Apobec3

  (MGI:1933111)

• Gt(ROSA)26Sor^{tm1(CAG-APOBEC3B)Rshar} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  chicken	CAG

• Mutation details: A CAG promoter followed by a loxPStop (neomycin)loxP cassette and the human DNA mutating enzyme APOBEC3B were introduced to intron 1. (J:341577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1060 strains or lines available

References

• Original: J:341577 Durfee C, et al., Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases. Cell Rep Med. 2023 Oct 17;4(10):101211
• All: 2 reference(s)