Plvap^{tm1.1(cre/ERT2)Tng}
Targeted Allele Detail

Summary

• Symbol: Plvap^{tm1.1(cre/ERT2)Tng}
• Name: plasmalemma vesicle associated protein; targeted mutation 1.1, Takashi Nagasawa
• MGI ID: MGI:7461180
• Synonyms: Plvap^CreERT2
• Gene: Plvap Location: Chr8:71950409-71964396 bp, - strand Genetic Position: Chr8, 34.43 cM
• Alliance: Plvap^{tm1.1(cre/ERT2)Tng} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:328290
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Plvap^{tm1.1(cre/ERT2)Tng} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Plvap (MGI:1890497)

• Mutation details: A gene cassette composed of internal ribosome entry site (IRES), CreERT2 and a neomycin resistance (Neo) gene flanked between a pair of Frt sites was inserted into the 3'UTR region in the sixth exon of the Plvap gene, through the gene targeting method in ES cells. Neo sequence was subsequently removed from the recombinant allele by mating with a Flipper mouse line. (J:328290)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Plvap (mouse) Summary of all recombinase alleles driven by Plvap. Comparative matrix view of recombinase activities Alliance mouse Plvap gene page

Expression

In Mice Carrying this Mutation:

13 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plvap Mutation: 47 strains or lines available

References

• Original: J:328290 Nakagawa T, et al., A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis. Cell Rep. 2021 Oct 19;37(3):109875
• All: 1 reference(s)