Slc2a2^tm2.1Thor
Targeted Allele Detail

Summary

• Symbol: Slc2a2^tm2.1Thor
• Name: solute carrier family 2 (facilitated glucose transporter), member 2; targeted mutation 2.1, Bernard Thorens
• MGI ID: MGI:7451388
• Synonyms: Glut2^lox
• Gene: Slc2a2 Location: Chr3:28752052-28782510 bp, + strand Genetic Position: Chr3, 12.19 cM
• Alliance: Slc2a2^tm2.1Thor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 11. A loxP-FRT-PGK-neomycin-FRT was inserted downstream of exon 11. Western blot analysis confirmed normal protein expression in the liver. Flp mediated recombination removed the PGK neomycin cassette. (J:197607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc2a2 Mutation: 31 strains or lines available

Notes

The version of this allele that contains the neomycin selection cassette, Slc2a2^tm1Thor, has been analyzed.

References

• Original: J:197607 Seyer P, et al., Hepatic glucose sensing is required to preserve beta cell glucose competence. J Clin Invest. 2013 Apr 1;123(4):1662-76
• All: 2 reference(s)