Stat1^em1Jiche
Endonuclease-mediated Allele Detail

Summary

• Symbol: Stat1^em1Jiche
• Name: signal transducer and activator of transcription 1; endonuclease-mediated mutation 1, Ji-Long Chen
• MGI ID: MGI:7451260
• Synonyms: STAT1^Y701F
• Gene: Stat1 Location: Chr1:52158599-52201024 bp, + strand Genetic Position: Chr1, 26.81 cM
• Alliance: Stat1^em1Jiche page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Using CRISPR-Cas9, mutation corresponding to the phosphorylation at Y701 is changed to amino acid F. (J:304304)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat1 Mutation: 73 strains or lines available

References

• Original: J:304304 Liu S, et al., Critical role of Syk-dependent STAT1 activation in innate antiviral immunity. Cell Rep. 2021 Jan 19;34(3):108627
• All: 1 reference(s)