Tbx3^{em1(cre/ERT2)Toyo}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tbx3^{em1(cre/ERT2)Toyo}
• Name: T-box 3; endonuclease-mediated mutation 1, Fumiko Toyoshima
• MGI ID: MGI:7451039
• Synonyms: Tbx3creERT2
• Gene: Tbx3 Location: Chr5:119808734-119822789 bp, + strand Genetic Position: Chr5, 60.34 cM
• Alliance: Tbx3^{em1(cre/ERT2)Toyo} page

Mutation origin

• Strain of Origin: ICR

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Mutation: Insertion
• Tbx3^{em1(cre/ERT2)Toyo} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tbx3 (MGI:98495)

• Using CRISPR/Cas9 technology, a 2A-CreERT2 cassette was inserted into the Tbx3 locus. (J:303437)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tbx3 (mouse) Summary of all recombinase alleles driven by Tbx3. Comparative matrix view of recombinase activities Alliance mouse Tbx3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tbx3 Mutation: 49 strains or lines available

References

• Original: J:303437 Ichijo R, et al., Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs. Sci Adv. 2021 Feb;7(7)
• All: 1 reference(s)