Aldh1l1^{em1(cre/ERT2)Nju}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Aldh1l1^{em1(cre/ERT2)Nju}
• Name: aldehyde dehydrogenase 1 family, member L1; endonuclease-mediated mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:7450881
• Synonyms: Aldh1l1-CreER^T2
• Gene: Aldh1l1 Location: Chr6:90527751-90576153 bp, + strand Genetic Position: Chr6, 40.16 cM
• Alliance: Aldh1l1^{em1(cre/ERT2)Nju} page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Aldh1l1^{em1(cre/ERT2)Nju} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Aldh1l1 (MGI:1340024)

• Mutation details: Using a CRISPR/Cas9 system, the T2A-CreERT2 cassette was inserted into the exon containing the termination codon of the Aldh1l1. (J:330603)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1l1 (mouse) Summary of all recombinase alleles driven by Aldh1l1. Comparative matrix view of recombinase activities Alliance mouse Aldh1l1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh1l1 Mutation: 58 strains or lines available

References

• Original: J:330603 Hu NY, et al., Expression Patterns of Inducible Cre Recombinase Driven by Differential Astrocyte-Specific Promoters in Transgenic Mouse Lines. Neurosci Bull. 2020 May;36(5):530-544
• All: 3 reference(s)