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Endonuclease-mediated Allele Detail
Symbol: Ttc12em1(IMPC)J
Name: tetratricopeptide repeat domain 12; endonuclease-mediated mutation 1, Jackson
MGI ID: MGI:7450833
Gene: Ttc12  Location: Chr9:49348263-49397525 bp, - strand  Genetic Position: Chr9, 26.83 cM
Alliance: Ttc12em1(IMPC)J page
IMPC: Ttc12 gene page
Strain of Origin:  C57BL/6NJ
Project Collection: IMPC
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis allele was generated at The Jackson Laboratory by electroporating Cas9 protein and 2 guide sequences GCAAGGGTAGACAGTATCGT and GCTGGGCCAAACTAGAAAAC, which resulted in a 321 bp deletion beginning at Chromosome 9 position 49,470,103 bp and ending after 49,470,423 bp (GRCm38/mm10). This mutation deletes ENSMUSE00001296287 (exon 6) and 199 bp of flanking intronic sequence including the splice acceptor and donor and is predicted to cause a change of amino acid sequence after residue 106 and early truncation 15 amino acids later. There is a 5 bp insertion (TCACT) at the deletion site. (J:188991)
Inheritance:    Not Specified
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ttc12 Mutation:  13 strains or lines available
Original:  J:188991 The Jackson Laboratory, Alleles produced for the KOMP project by The Jackson Laboratory. MGI Direct Data Submission. 2012;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory