Dusp7^em2Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dusp7^em2Smoc
• Name: dual specificity phosphatase 7; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
• MGI ID: MGI:7450804
• Gene: Dusp7 Location: Chr9:106245831-106252923 bp, + strand Genetic Position: Chr9, 57.46 cM
• Alliance: Dusp7^em2Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology using sgRNAs 5-CTAGGCGGGCCCGTAGGAGCCGG-3 and 5-GTGGGTTTTCAGGCCAGAGGGG-3 deleted exons 1-3. (J:334132)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dusp7 Mutation: 16 strains or lines available

References

• Original: J:334132 Liu J, et al., Dual Specific Phosphatase 7 Exacerbates Dilated Cardiomyopathy, Heart Failure, and Cardiac Death by Inactivating the ERK1/2 Signaling Pathway. J Cardiovasc Transl Res. 2022 Dec;15(6):1219-1238
• All: 1 reference(s)