Abcg2^{tm1.1(cre/Esr1*)Jvbe}
Targeted Allele Detail

Summary

• Symbol: Abcg2^{tm1.1(cre/Esr1*)Jvbe}
• Name: ATP binding cassette subfamily G member 2 (Junior blood group); targeted mutation 1.1, Jop H van Berlo
• MGI ID: MGI:7449246
• Synonyms: Abcg2^MCM
• Gene: Abcg2 Location: Chr6:58561476-58669436 bp, + strand
• Alliance: Abcg2^{tm1.1(cre/Esr1*)Jvbe} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304949
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Abcg2^{tm1.1(cre/Esr1*)Jvbe} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Abcg2 (MGI:1347061)

• Mutation details: A cDNA encoding MerCreMer (cre recombinase fused to two modified estrogen receptor ligand binding domains at both ends), and an frt-flanked neomycin selection cassette were cloned in-frame with the Acbdg2 ATG start codon containing a second exon of Abcg2. Homologous recombination was performed in ES cells, and chimeras were bred to flp-expressing knock-in mice to delete the selection marker. (J:304949)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Abcg2 (mouse) Summary of all recombinase alleles driven by Abcg2. Comparative matrix view of recombinase activities Alliance mouse Abcg2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcg2 Mutation: 74 strains or lines available

References

• Original: J:304949 Yellamilli A, et al., Abcg2-expressing side population cells contribute to cardiomyocyte renewal through fusion. FASEB J. 2020 Apr;34(4):5642-5657
• All: 1 reference(s)