Lrrc8d^em2Tjj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc8d^em2Tjj
• Name: leucine rich repeat containing 8D; endonuclease-mediated mutation 2, Thomas J Jentsch
• MGI ID: MGI:7447499
• Synonyms: Lrrc8d^TdTlox
• Gene: Lrrc8d Location: Chr5:105847829-105963081 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Lrrc8d^em2Tjj page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: CRISPR/Cas9 technology was utilized to fuse the sequence encoding tdTomato fluorescent protein to the carboxy-terminus end of the gene. (J:263622)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc8d Mutation: 67 strains or lines available

References

• Original: J:263622 Stuhlmann T, et al., LRRC8/VRAC anion channels enhance beta-cell glucose sensing and insulin secretion. Nat Commun. 2018 May 17;9(1):1974
• All: 2 reference(s)