Lrrc8d^em1Tjj
Endonuclease-mediated Allele Detail

Summary

• Symbol: Lrrc8d^em1Tjj
• Name: leucine rich repeat containing 8D; endonuclease-mediated mutation 1, Thomas J Jentsch
• MGI ID: MGI:7447478
• Gene: Lrrc8d Location: Chr5:105847829-105963081 bp, + strand Genetic Position: Chr5, 50.68 cM
• Alliance: Lrrc8d^em1Tjj page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology generated a 14 bp deletion (nucleotides 43-56) resulting in an early stop codon before the first transmembrane domain. (J:333948)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrc8d Mutation: 67 strains or lines available

References

• Original: J:333948 Lopez-Cayuqueo KI, et al., Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy. J Am Soc Nephrol. 2022 Aug;33(8):1528-1545
• All: 1 reference(s)