Rab37^tm1Hsliu
Targeted Allele Detail

Summary

• Symbol: Rab37^tm1Hsliu
• Name: RAB37, member RAS oncogene family; targeted mutation 1, Hsiao-Sheng Liu
• MGI ID: MGI:7447468
• Gene: Rab37 Location: Chr11:114982257-115053062 bp, + strand Genetic Position: Chr11, 80.59 cM, cytoband E2
• Alliance: Rab37^tm1Hsliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:334080
• Parent Cell Line: JM8A3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The targeting construct replaced exons 1 and 2 with a neomycin resistance cassette. (J:334080)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab37 Mutation: 19 strains or lines available

References

• Original: J:334080 Wu SY, et al., Secretory autophagy promotes RAB37-mediated insulin secretion under glucose stimulation both in vitro and in vivo. Autophagy. 2023 Apr;19(4):1239-1257
• All: 1 reference(s)