Slamf7^em1Yaa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slamf7^em1Yaa
• Name: SLAM family member 7; endonuclease-mediated mutation 1, Yasser A Aldhamen
• MGI ID: MGI:7447215
• Gene: Slamf7 Location: Chr1:171459971-171480603 bp, - strand Genetic Position: Chr1, 79.54 cM, cytoband H2
• Alliance: Slamf7^em1Yaa page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 3-5. (J:325759)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slamf7 Mutation: 19 strains or lines available

References

• Original: J:325759 O'Connell P, et al., SLAMF7 Signaling Reprograms T Cells toward Exhaustion in the Tumor Microenvironment. J Immunol. 2021 Jan 1;206(1):193-205
• All: 2 reference(s)