Mc4r^em2(cre)Vai
Endonuclease-mediated Allele Detail

Summary

• Symbol: Mc4r^em2(cre)Vai
• Name: melanocortin 4 receptor; endonuclease-mediated mutation 2, Christian Vaisse
• MGI ID: MGI:7447190
• Synonyms: MC4R^t2aCre, Mc4r^{tm2(t2a Cre)Vai}
• Gene: Mc4r Location: Chr18:66990776-66993558 bp, - strand Genetic Position: Chr18, 39.72 cM, cytoband E1
• Alliance: Mc4r^em2(cre)Vai page

Mutation origin

• Strain of Origin: FVB/N

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Mc4r^em2(cre)Vai expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Mc4r (MGI:99457)

• Mutation details: A t2a-Cre sequence was inserted in-frame immediately downstream of following the Mc4r stop codon by CRISPR-Cas9. (J:334174)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Mc4r (mouse) Summary of all recombinase alleles driven by Mc4r. Comparative matrix view of recombinase activities Alliance mouse Mc4r gene page

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mc4r Mutation: 44 strains or lines available

References

• Original: J:334174 Wang Y, et al., Melanocortin 4 receptor signals at the neuronal primary cilium to control food intake and body weight. J Clin Invest. 2021 May 3;131(9)
• All: 2 reference(s)