Lyz1^{tm3.1(Hbegf)Cle}
Targeted Allele Detail

Summary

• Symbol: Lyz1^{tm3.1(Hbegf)Cle}
• Name: lysozyme 1; targeted mutation 3.1 Hans Clevers
• MGI ID: MGI:7447076
• Synonyms: Lyz1^{tm3.1(DTR)Cle}, pLys-^DTR
• Gene: Lyz1 Location: Chr10:117123702-117128773 bp, - strand Genetic Position: Chr10, 65.35 cM
• Alliance: Lyz1^{tm3.1(Hbegf)Cle} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:285915
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Lyz1^{tm3.1(Hbegf)Cle} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: A DTR gene was inserted onto the ATG of the Lyz1 gene through homologous recombination in ES cells. The neomycin selection cassette was flanked by Frt recombination sites and excised in vivo by crossing the mice with the general FLP deleter strain. (J:285915)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lyz1 Mutation: 17 strains or lines available

References

• Original: J:285915 van Es JH, et al., Enteroendocrine and tuft cells support Lgr5 stem cells on Paneth cell depletion. Proc Natl Acad Sci U S A. 2019 Dec 16
• All: 1 reference(s)