Ptf1a^{tm1(flpo)Hcrd}
Targeted Allele Detail

Summary

• Symbol: Ptf1a^{tm1(flpo)Hcrd}
• Name: pancreas specific transcription factor, 1a; targeted mutation 1, Howard C Crawford
• MGI ID: MGI:7447045
• Synonyms: Ptf1a^FlpO
• Gene: Ptf1a Location: Chr2:19450474-19452312 bp, + strand Genetic Position: Chr2, 13.37 cM, cytoband A2
• Alliance: Ptf1a^{tm1(flpo)Hcrd} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:294489
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Recombinase)
• Mutations: Insertion, Intragenic deletion
• Ptf1a^{tm1(flpo)Hcrd} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ptf1a (MGI:1328312)

• Mutation details: The entire coding region was replaced with a cassette containing Flpo recombinase and Frt flanked hygromycin resistance gene by RMCE using Ptf1a^tm1Mgn. (J:294489)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ptf1a (mouse) Summary of all recombinase alleles driven by Ptf1a. Comparative matrix view of recombinase activities Alliance mouse Ptf1a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptf1a Mutation: 30 strains or lines available

References

• Original: J:294489 Wen HJ, et al., Myeloid Cell-Derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;8(2):173-192
• All: 2 reference(s)