Fzr1^em1Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fzr1^em1Cya
• Name: fizzy and cell division cycle 20 related 1; endonuclease-mediated mutation 1, Cyagen Biosciences
• MGI ID: MGI:7446456
• Gene: Fzr1 Location: Chr10:81202713-81214204 bp, - strand Genetic Position: Chr10, 39.72 cM
• Alliance: Fzr1^em1Cya page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology deleted exons 5 to 8. (J:321560)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fzr1 Mutation: 43 strains or lines available

References

• Original: J:321560 Zhou C, et al., Insufficiency of FZR1 disturbs HSC quiescence by inhibiting ubiquitin-dependent degradation of RUNX1 in aplastic anemia. Leukemia. 2022 Mar;36(3):834-846
• All: 1 reference(s)