Nfib^em1Mtb
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nfib^em1Mtb
• Name: nuclear factor I/B; endonuclease-mediated mutation 1, Mark T Bedford
• MGI ID: MGI:7446426
• Synonyms: Nfib^R388K
• Gene: Nfib Location: Chr4:82208410-82424988 bp, - strand Genetic Position: Chr4, 38.4 cM, cytoband C4-C6
• Alliance: Nfib^em1Mtb page

Mutation origin

• Strain of Origin: C57BL/6JGpt

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting introduced the mutation responsible for the amino acid substitution arginine with lysine at position 388 (R388K). (J:332811)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfib Mutation: 93 strains or lines available

References

• Original: J:332811 Gao G, et al., The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer. Nat Commun. 2023 Jan 23;14(1):363
• All: 1 reference(s)