Fmr1^em1Gfng
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fmr1^em1Gfng
• Name: fragile X messenger ribonucleoprotein 1; endonuclease-mediated mutation 1, Guoping Feng
• MGI ID: MGI:7444995
• Synonyms: Fmr1^hs341
• Gene: Fmr1 Location: ChrX:67722147-67761569 bp, + strand Genetic Position: ChrX, 34.83 cM
• Alliance: Fmr1^em1Gfng page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 genome editing techniques are used to replace the endogenous 6 CGG repeat sequence in the 5'; UTR of the gene with a human patient cell line derived 341 CGG repeat sequence. (J:334060)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fmr1 Mutation: 30 strains or lines available

References

• Original: J:334060 Colvin S, et al., 341 Repeats Is Not Enough for Methylation in a New Fragile X Mouse Model. eNeuro. 2022 Sep-Oct;9(5):ENEURO.0142-22.2022
• All: 1 reference(s)