Rxfp1^{tm2(RXFP1)Aia}
Targeted Allele Detail

Summary

• Symbol: Rxfp1^{tm2(RXFP1)Aia}
• Name: relaxin/insulin-like family peptide receptor 1; targeted mutation 2, Alexander I Agoulnik
• MGI ID: MGI:7444966
• Synonyms: hRXFP1
• Gene: Rxfp1 Location: Chr3:79548918-79645187 bp, - strand Genetic Position: Chr3, 34.94 cM
• Alliance: Rxfp1^{tm2(RXFP1)Aia} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312607
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Null/knockout)
• Mutations: Duplication, Insertion
• Rxfp1^{tm2(RXFP1)Aia} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RXFP1 (59350)

  Rxfp1

  (MGI:2682211)

• Mutation details: The targeting vector contains an internal ribosome entry site (IRES) fused to full length human relaxin/insulin-like family peptide receptor 1 (RXFP1) cDNA, followed by a loxP-flanked neomycin resistance (neo) cassette, inserted into exon 17 of the endogenous Rxfp1 gene. The vector also includes duplication of endogenous exon 16 and parts of endogenous exons 15 and 17. (J:312607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rxfp1 Mutation: 53 strains or lines available

References

• Original: J:312607 Kaftanovskaya EM, et al., Human Relaxin Receptor Is Fully Functional in Humanized Mice and Is Activated by Small Molecule Agonist ML290. J Endocr Soc. 2017 Jun;1(6):712-725
• All: 1 reference(s)