Igdmr^em3Takas
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igdmr^em3Takas
• Name: intergenic germline-derived differentially methylated region; endonuclease-mediated mutation 3, Shuji Takada
• MGI ID: MGI:7444822
• Synonyms: IG-DMR^hRep
• Gene: Igdmr Location: Chr12:109492765-109496915 bp Genetic Position: Chr12, Syntenic
• Alliance: Igdmr^em3Takas page

Mutation origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Mutation description

• Allele Type: Endonuclease-mediated (Humanized sequence, Modified regulatory region)
• Mutations: Insertion, Intergenic deletion
• Mutation details: CRISPR-cas9 mediated recombination replaced the mouse 216 bp, 24 bp by 7 repeats, domain with the homologous 160 bp, 18 bp by 9 repeats, domain from human. (J:310159)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igdmr Mutation: 2 strains or lines available

References

• Original: J:310159 Hara S, et al., Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse Dlk1-Dio3 domain. Hum Mol Genet. 2021 May 12;30(7):564-574
• All: 1 reference(s)