Clic1^tm1Jce
Targeted Allele Detail

Summary

• Symbol: Clic1^tm1Jce
• Name: chloride intracellular channel 1; targeted mutation 1, John C Edwards
• MGI ID: MGI:7444821
• Gene: Clic1 Location: Chr17:35269219-35277695 bp, + strand Genetic Position: Chr17, 18.58 cM
• Alliance: Clic1^tm1Jce page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:311061
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic sequence spanning exons 2 - 4 was replaced with a floxed selection cassette via homologous recombination. (J:311061)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clic1 Mutation: 17 strains or lines available

References

• Original: J:311061 Ulmasov B, et al., CLIC1 null mice demonstrate a role for CLIC1 in macrophage superoxide production and tissue injury. Physiol Rep. 2017 Mar;5(5)
• All: 2 reference(s)