Ryr1^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Ryr1^tm1Ics
• Name: ryanodine receptor 1, skeletal muscle; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:7444819
• Synonyms: Ryr1^Flox
• Gene: Ryr1 Location: Chr7:28702765-28824599 bp, - strand Genetic Position: Chr7, 16.94 cM, cytoband A2-B3
• Alliance: Ryr1^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:312214
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• LoxP sites were inserted around exons 9 - 11 via homologous recombination. (J:312214)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ryr1 Mutation: 215 strains or lines available

References

• Original: J:312214 Pelletier L, et al., In vivo RyR1 reduction in muscle triggers a core-like myopathy. Acta Neuropathol Commun. 2020 Nov 11;8(1):192
• All: 1 reference(s)