Arhgef2^em1Huhao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Arhgef2^em1Huhao
• Name: Rho/Rac guanine nucleotide exchange factor 2; endonuclease-mediated mutation 1, Hao Hu
• MGI ID: MGI:7444815
• Gene: Arhgef2 Location: Chr3:88513273-88555359 bp, + strand Genetic Position: Chr3, 38.9 cM, cytoband F1
• Alliance: Arhgef2^em1Huhao page

Mutation origin

• Strain of Origin: Not Applicable

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-cas9 mediated recombination using guide RNAs targeting exon 2 created a 581 bp deletion. (J:312216)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgef2 Mutation: 78 strains or lines available

References

• Original: J:312216 Zhou P, et al., Arhgef2 regulates neural differentiation in the cerebral cortex through mRNA m(6)A-methylation of Npdc1 and Cend1. iScience. 2021 Jun 25;24(6):102645
• All: 1 reference(s)