Fbxw7^em1Axbe
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fbxw7^em1Axbe
• Name: F-box and WD-40 domain protein 7; endonuclease-mediated mutation 1, Axel Behrens
• MGI ID: MGI:7444814
• Synonyms: Fbxw7^FRT
• Gene: Fbxw7 Location: Chr3:84722575-84886505 bp, + strand Genetic Position: Chr3, 37.7 cM, cytoband E3.3
• Alliance: Fbxw7^em1Axbe page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• CRISPR-cas9 mediated recombination using guide RNAs inserted FRT sites into introns 4 and 5. (J:312398)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxw7 Mutation: 81 strains or lines available

References

• Original: J:312398 Ruiz EJ, et al., USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. Elife. 2021 Oct 12;10:e71596
• All: 1 reference(s)